Publications

Pigati L, Yaddanapudi S, Iyengar R, Kim DJ, Hearn S, Danforth D, Hastings ML, Duelli DM. (2010) Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells. PLoS One.
http://dx.plos.org/10.1371/journal.pone.0013515

Jodelka FM, Ebert AD, Duelli DM, Hastings ML. (2010) A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum Mol Genet. 2010 Sep 30. doi: 10.1093/hmg/ddq425
PMID: 20884664
http://hmg.oxfordjournals.org/content/early/2010/10/13/hmg.ddq425.long

Duelli D. and Lazebnik Y. (2007) Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer. 7(12): 968-976.
PMID: 18034186
http://www.nature.com/nrc/journal/v7/n12/full/nrc2272.html

Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (2007) Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF. PLoS ONE 2: e538.
PMID: 17579712
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000538

Duelli DM, Padilla-Nash H, Berman D, Murphy KM, Ried T, Lazebnik Y (2007) A virus causes cancer by inducing massive chromosomal instability through cell fusion. Current Biology 17 (5): 431-437. PMID: 17320392

Duelli DM, Hearn S, Myers MP, Lazebnik Y (2005) A primate virus generates transformed human cells by fusion. Journal of Cell Biology 171 (3): 493-503. PMID: 16275753

Duelli D and Lazebnik Y (2003) Cell fusion: A hidden enemy? Cancer Cell 3 (5):445-448.

Duelli DM, Tobin A, Box JM, Kolli VS, Carlson RW, Noel KD (2001) Genetic locus required for antigenic maturation of Rhizobium etli CE3 lipopolysaccharide. Journal of Bacteriology 183 (20): 6054-6064. PMID: 11567006

Duelli DM and Lazebnik YA (2000) Primary cells suppress oncogene-dependent apoptosis. Nature Cell Biology 2 (11): 859-862. PMID: 11056544

Duelli DM and Noel KD (1997) Compounds exuded by Phaseolus vulgaris that induce a modification of Rhizobium etli lipopolysaccharide. Mol. Plant-Microbe Interact. 10: 903-910.

Noel KD, Duelli DM, Tao H, Brewin NJ (1996) Antigenic change in the lipopolysaccharide of Rhizobium etli CFN42 induced by exudates of Phaseolus vulgaris. Mol. Plant-Microbe Interact. 9:180-186.

Comments on our work:

Research Highlights, Nature 438, 260-261

Vile RG, News and Commentary, Gene Ther. 2006 13, 1127-30.

Research Highlights, Nature Reviews Cancer 7, 230
Nature Reviews Microbiology, 5, 244, 2007
Comment in New Scientist 12, 2593, 2007.

Research Support

Grant # 189903	Duelli (PI)	1/1/2011-12/31/2011
American Cancer Society Mechanism of Selective MicroRNA Release from Cancer Cells. The goal of this study is to identify the mechanism by which oncogenic transformation changes the cellular export machinery that releases miRNAs into the environment.
BC076659	Duelli (PI)	11/01/2008-10/31/2009
Department of Defense Breast Cancer Research Program (BCRP), Concept Award. MicroRNAs of Exosomes for Early Detection of Mammary Neoplasms. The goal of this study was to develop tools and protocols to enrich for mammary exosomes from body fluids to identify sets of exosomal miRNAs that predict tumorigenesis and tumor progression.
Research Grant 08-29	Duelli (PI)	5/01/2008-4/30/2009
American Cancer Society. Oncogene-Dependent Apoptosis in Tetraploidy-Induced Tumorigenesis. The goal of this study was to identify oncogenic domains and regulators of the apoptotic pathway required for oncogene-dependent apoptosis induced by tetraploidy.

Patents:

US Provisional Patent Application: MICRO RNAS AS A DIAGNOSTIC FOR THE EXISTENCE OF CANCER AND AS A PROGNOSTIC FOR CANCER TREATMENT, USSN 61/394,953,
Filed October 20, 2010, RDL Case No. 112461.00078, Inventor: Dominik M. Duelli